The large number of people in our study means we have provided the strongest evidence to date that ‘night owls’ are at higher risk of mental health problems, such as schizophrenia and lower mental well-being, although further studies are needed to fully understand this link.” Michael Weedon of the University of Exeter Medical School, who led the research, said, “This study highlights a large number of genes which can be studied in more detail to work out how different people can have different body clocks. It also increased the number of areas of the genome known to influence whether someone is an early riser from 24 to 351. It highlighted the key role of the retina in helping the body keep time. The study was conducted by an international collaboration, led by the University of Exeter and Harvard-affiliated Massachusetts General Hospital (MGH) and funded primarily by the Medical Research Council of the U.K. However, despite much previous speculation, the results did not reveal any strong links to diseases such as diabetes or obesity. The study, published in Nature Communications, suggests that being genetically programmed to rise early may lead to greater well-being and a lower risk of schizophrenia and depression. EXETER, U.K./BOSTON - A large-scale genomic analysis has revealed some of the inner workings of the body clock, shedding new light on how it links to mental health and disease.
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